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Fish Oil Plus Red Yeast Rice Match Statins For Cholesterol Cuts

09-Jul-2008 - A combination of fish oils, red yeast rice and other lifestyle changes reduced cholesterol levels by the same amount as a daily statin pill, according to new research. Levels of LDL-cholesterol were reduced by 42.4 per cent following consumption of the fish oil and red yeast rice combination, compared to reductions of 39.6 per cent in the statin group, according to results of a randomised trial published in the Mayo Clinic Proceedings.

"These results are intriguing and show a potential benefit of an alternative, or naturopathic, approach to a common medical condition," said David Becker, MD, from the University of Pennsylvania Health System.

High cholesterol levels, hypercholesterolaemia, have a long association with many diseases, particularly cardiovascular disease. CVD causes almost 50 per cent of deaths in Europe, and is reported to cost the EU economy an estimated €169bn ($202bn) per year. According to the American Heart Association, 34.2 per cent of Americans (70.1m people) suffered from some form of cardiovascular disease (CVD) in 2002.

Study details

Becker and co-workers recruited 74 people with hypercholesterolaemia and randomly assigned them to receive a daily statin dose of simvastatin (40 mg/d) or the fish oil (EPA 2106 mg/d, DHA 1680 mg/d, N3 Oceanic) and red yeast rice (N3 Oceanic). The red yeast rice contained a total monacolin content of 5.3 mg, with 2.53 mg in the form of monacolin K (lovastatin).

Red yeast rice is the product of yeast grown on rice. It is a dietary staple in some Asian countries, and reportedly contains several compounds that inhibit cholesterol production.

After 12 weeks of intervention, the researchers found statistically significant LDL reductions in both groups, but no difference between the groups.

In addition to the LDL cuts, the fish oil/ red yeast rice combination also produced significant reductions in triglyceride levels of 29 per cent, compared to a non-significant nine per cent reduction in the statin group.

"Lifestyle changes combined with ingestion of red yeast rice and fish oil reduced LDL-C in proportions similar to standard therapy with simvastatin," wrote the researchers.

"Pending confirmation in larger trials, this multifactorial, alternative approach to lipid lowering has promise for a subset of patients unwilling or unable to take statins," they added.

Mechanisms

"Red yeast rice contains naturally occurring lovastatin and nine different substances called monacolins that could inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase," wrote Becker and co-workers.

"The dose of RYR in our study (2.4-3.6 g/d) was equivalent to a daily lovastatin dose of 10 to 15 mg, less than the established therapeutic dose (20-40 mg)."

The reductions in triglyceride levels observed in the study were put down to the fish oil part of the combination.

"The triglyceride -lowering effects of fish oil have been established and could be responsible for the results observed in the current study," they added.

How to Increase Fat Burning by 30%!

A proven and simple fat loss technique that is often overlooked is water consumption. Researchers from Humboldt University, utilizing a technique known as whole-room indirect calorimetry, discovered that drinking water activates your body's natural ability to burn fat.

Drinking 500 ml (16 ounces) of water in one sitting increased metabolic rate by a whopping 30%! To harness this simple fat burning technique drink 16 ounces of purified water upon waking and 5 minutes before every meal...... Pant sizes will decrease.

Cinnamon Health Benefits

You may be interested to know natural simple ways to improve your health. Here, we have something as simple as cinnamon could help your well being in poorly known ways. Take a look….

Boron and Your Prostate Health

Here is another superb article from Dr. Sears, regarding boron and prostate cancer. Read it and take the necessary life changes to accommodate it in your daily routine.

BUY OMEGA 3 Omega 3 / DHA Esters

If you want to have an idea of how the omega 3 demand and awareness increases everyday, take a look at this news release about how the fish oil market will be “swelling” to 7 billions a year by 2.011.

A recent article in Life Extension Magazine have this interesting subject for all diabetics, or potential diabetics (we all are), regarding a new study comparing the omega 3 ingestion with diabetes risks.

An increased intake of omega-3 fatty acids may decrease the risk of developing type 1 diabetes, according to a study published in JAMA(Journal of American Medical Association)

News on Fish Oil, Omega 3, Diet, Exercise and Anything Significant in Health.

żIs Stress Fattening You?

Insulin regulates fat storage in our body. Some of us, when we are stressed have the tendency to eat sweets but there is a better way to deal with emotional tension: concentrate in your breathing.

Do not try to change your breathing, just feel it, watch it, observe it…. Do it while you are reading this. Notice what muscles are working, how smoothly, it changes from inhaling to exhaling, feel every part of your body. This concentration in your breathing is by itself a therapy.

Try to make exhaling longer, just a little. Slowly, exhale a little more air. Feel the tension release.

This type of concentration in your breathing can reach every part of your body. Your muscles relax and you recharge. Your mind stops and your cortisol levels decrease…You are ready for the world again. Make this a daily practice for 5 minutes twice a day and you will feel the difference.

Study Relating Alzheimers DHA - Omega 3

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High Cholesterol+History of Heart Disease+Fish Oil + Statin= Less Risks of Major Coronary Event

Fish-oil supplements added to statin therapy can further reduce the risk of major coronary events, even among patients who already eat a diet heavy in fish, investigators here reported.

Among more than 18,000 patients with hypercholesterolemia and a history of coronary artery disease, the addition to statins of eicosapentaenoic acid, a long-chain-n-3 fatty acid in fish oil, reduced the occurrence of major coronary events by 19% over statins alone, reported Mitsuhiro Yokoyama, M.D., from Kobe University here, and colleagues.

Eicosapentaenoic acid, (EPA) was associated with significant reductions in unstable angina and non-fatal coronary events, but there were no differences in either sudden cardiac death or coronary death, the investigators in the Japan EPA Lipid Intervention Study (JELIS).wrote in the March 31 issue of The Lancet.

The JELIS investigators recruited 18,645 patients from 1996 to 1999, with a total cholesterol of 6.5 mmol/L (253 mg/dL) or greater. The patients were randomly assigned to 1,800 mg of EPA daily with a statin (9,326 patients) or statin therapy alone (9,319).

EPA was given at a dose of 600 mg, three times a day after meals (to a total of 1,800 mg per day). Statin therapy was initiated with either 10 mg of pravastatin (Pravachol) or 5 mg of simvastatin (Zocor) once daily as first-line treatment. For patients with uncontrolled hypercholesterolemia, the daily dose could be increased to 20 mg of pravastatin or 10 mg of simvastatin.

The primary endpoint was any major coronary event, including sudden cardiac death, fatal and non-fatal MI, and other nonfatal events, including unstable angina, angioplasty, stenting, or coronary artery bypass graft. Follow-up was for five years, with analysis by intention-to-treat.

The ‘standard’ medical solution for high cholesterol is to prescribe a statin drug. Whereas these are generally effective in lowering cholesterol…some people pay a price…in side effects! These can range from damaged livers, muscle aches and even impotency. You may want to check this information.

In both groups, LDL concentrations decreased by 25%, from a mean of 4.7 mmol/L (183 mg/dL) at baseline, and total cholesterol declined by 19%.

The omega-3 fatty acid was also associated with a significant reduction of 24% in the frequency of unstable angina, although there were no significant differences in the rate of either coronary death or myocardial infarction between the groups.

"The frequency of fatal or non-fatal myocardial infarction was not significantly reduced (23%) in the EPA group," the authors wrote. "However, that of non-fatal coronary events (including non-fatal myocardial infarction, unstable angina, and events of angioplasty, stenting, or coronary artery bypass grafting) was significantly lower (19%) in the EPA group than in controls."

Yet in a subgroup of patients with coronary artery disease who had already suffered a major coronary event (secondary prevention group), EPA treatment was associated with a significant 19% reduction in total major coronary events, and a 28% reduction in the incidence of unstable angina. That the authors did not see an effect of EPA on mortality is not surprising, Dr. Mozaffarian commented. "In Japan, average fish consumption is one serving of 85 g (3 oz; 900 mg EPA and DHA) per day, and 90% of individuals eat fish at least once a week," he wrote. "Thus, most of the population is already above the threshold for preventing cardiac death. In any such population, one would expect low baseline rates of cardiac death, and little further reduction in cardiac death with additional fish-oil consumption."

He also noted that the reduction in non-fatal events was consistent with findings of observational studies of Japanese populations and some U.S populations with high levels of fish consumption.

Omega 3 and Heart Disease Protection

People with high cholesterol levels and taking statins reduced their frequency of major cardiac events by about 20 per cent when supplemented with the omega-3 of eicosapentaenoic acid (EPA), researchers have reported.

The research, published in this week's issue of The Lancet, followed 18 645 Japanese patients with high cholesterol levels (hypercholesterolaemia) taking statins, and randomly assigned half to receive a daily EPA supplement (1.8 g).

For more information, please go to Omega 3 and Heart Disease Protection

Many heart attacks and strokes occur because of hardening and narrowing of the arteries due to the build up of plaque and fatty deposits within them. you may want check this information.

How to Reduce Your Cell Phone Risks

Soy and Colesterol.

Some people have the idea that soy is a healthy food, specially good for the heart and hormones. It may be important to warn these people about soy’s negative influence in cardiovascular and hormonal health. It can increase homocystein and mimic estrogen hormones.

But what can we say about the noise we hear in the media these days about soy for cholesterol?. A careful review of the studies suggest that soy is not an effective way to lower cholesterol.

Nevertheless, there are several foods that can help to improve your cholesterol. Specially almonds. A recent study in men showed that raw or roasted almonds helped to improve cholesterol in 4 weeks.

How to Avoid Becoming a Fat Thin Person.

Whether your goal is to lose weight or just "tone up," your objective should be the same: to lose fat without sacrificing muscle. Otherwise, you'll just end up as a fat thin person.
we've told you exactly how to do this: Base all your meals around a healthy source of protein and add resistance exercise to your workout routine. Recent research published in the Journal of Nutrition confirms this approach.

When the study concluded, the high-protein group had lost an average of 22 pounds - almost all of it from fat. The women on the high-carbohydrate diet lost only 15 pounds, and more than two pounds of that was muscle. In other words, 15% of their weight loss was from muscle!

Dr. Donald Layman, the author of the study, summed it up this way:

"Both diets work because, when you restrict calories, you lose weight. But the people on the higher-protein diet lost more weight. There's an additive, interactive effect when a protein-rich diet is combined with exercise. The two work together to correct body composition; dieters lose more weight, and they lose fat, not muscle."

- Jon Herring

Over 95% of Anti-aging and Supplement programs do not work! Either because they are not scientifically formulated, are incomplete or, they contain inferior ingredients. In some cases due to poor manufacturing processes many products do not even contain the stated ingredients at all! Learn more by clicking here.

Higher Level Of Certain Fatty Acid Associated With Lower Dementia Risk

Age, family history and genetic factors have all been found to increase the risk of dementia and Alzheimer's disease, a neurodegenerative disorder that causes 70 percent of cases of dementia in the elderly, according to background information in the article. Recent studies have found that high levels of homocysteine, an amino acid that is derived from proteins in the diet and that can accumulate in the blood and contribute to heart disease, increase the risk for Alzheimer's disease and dementia. In addition, DHA, an omega-3 polyunsaturated fatty acid found in fish, appears to affect dementia risk and to be important for the proper functioning of the central nervous system.

Ernst J. Schaefer, M.D., Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, and colleagues studied the association between DHA levels and dementia in the blood of 899 men and women who were part of the population-based Framingham Heart Study. The participants of an average age of 76 years provided blood samples and underwent neuropsychological testing, and were followed for an average of nine years. A subgroup of 488 also filled out a questionnaire assessing their diet, including information about fish consumption. None of the participants had dementia at the beginning of the study; and they were given a mental examination every two years to screen for its development.

Through the nine-year study period, 99 out of 899 participants developed dementia, including 71 with Alzheimer's disease. After controlling for other known risk factors for dementia, including age and homocysteine levels, and dividing the study population into fourths (quartiles) based on levels of DHA, the researchers found that men and women in the quartile with the highest DHA levels had a 47 percent lower risk of developing dementia and 39 percent lower risk of developing Alzheimer's disease than the other three quartiles with lower DHA levels. Among the participants who completed the dietary questionnaire, those in the top quartile of blood DHA levels reported that they ate an average of .18 grams of DHA a day and an average of three fish servings a week. Participants in the other quartiles ate substantially less fish.

DHA levels in the blood vary by the degree to which the liver converts alpha-linolenic acid, an essential fatty acid, to DHA and also by the amount of DHA in the diet. "In our study, the correlation between [blood] DHA content and fish intake was significant, indicating that fish intake is an important source of dietary DHA," the authors write.

"In the future, it will also be important to determine whether combined dietary supplementation with DHA can decrease further mental deterioration in patients with established dementia," they conclude.

No doubt that it is better to be thin than fat, but even then, when you are not really ready to get down to your ideal weight, there are certain healthy habits you could incorporate into your daily life that will improve your overall health and well-being.

Take a look at this news from Reuters. It talks about doing some changes in diet and exercise that would benefit everybody

Here, in this report ScienceDaily tell us how the amounts on DHA(a major component of Omega 3) in the blood of patients is a direct indication of the risks of dementia and Alzheimer’s disease."Enter Any Words About Fish Oil"

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